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What is NEMO?
NEMO is the name of a gene that regulates functions of the immune
system. NEMO stands for Nuclear Factor Kappa B
Essential Modulator. It's like a "master switch" that is found on the cell of the human
body and regulates signals between the cell membrane and the cell
nucleus. It's expressed in almost all tissue cells. If NEMO is not
present life is not possible.
Nuclear Factor Kappa B or NFKB is the name of the protein that is used
for communication between the membrane and the nucleus. NEMO is known
to be the pathway of skin, skeleton, blood vessel and other vital
signals. For example, the EDA gene is known to dictate properties of
the "ectoderm" or last layer of the skin. The EDA gene uses the NEMO
pathway to the nucleus to make the "ectoderm" properties present.
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What is ECTODERMAL
DYSPLASIA?
The ectoderm is the outer layer of the skin, sweat glands, hair, teeth and
nails. Ectodermal dysplasia (ED) is a heritable disorder that affects the
ectoderm, the outer layer of tissue in a developing baby. ED syndromes
affect both males and females of all races and ethnic groups. The ectoderm
contributes to the formation of many parts of the body, including the
skin, sweat glands, hair, teeth, and nails. During embryonic development,
these and/or other parts of the baby’s body, including the lens of the
eye, parts of the inner ear, the fingers and toes, or nerves, among
others, may fail to develop normally.
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